The main bone marrow diseases are leukaemia, aplastic anaemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Leukaemia is a cancer of the white blood cells, and symptoms may include fatigue, pale skin, fever, frequent infections, and shortness of breath. Diagnosis is typically done with a physical examination, blood tests, imaging tests, and a bone marrow biopsy. Aplastic anaemia is a deficiency of all cell types in the bone marrow, and symptoms may include fatigue, paleness, infections, and shortness of breath. Diagnosis requires a physical examination, blood tests, imaging tests, and sometimes a bone marrow biopsy. Myelodysplastic syndromes are a group of disorders in which the bone marrow does not make enough healthy blood cells, and symptoms may include fatigue, paleness, easy bruising, and frequent infections. Diagnosis is typically done with a physical examination, blood tests, imaging tests, and a bone marrow biopsy. Myeloproliferative neoplasms are a group ...